VET. PRESCRIPTION
- Food designed to support therapy in dogs of all breeds undergoing an acute hepatic condition clinically diagnosed by a veterinarian.
Adult · Senior
Hepatic
Continuous therapeutic hepatic nutrition
Presentations
2 kg
Guaranteed analysis
Guaranteed Analysis
Guaranteed Analysis Table with minimum and maximum nutritional values certified by batch on a dry matter basis.
Values on a dry matter basis. See the full technical sheet for detailed analysis.
Mín. 16.0%
PROTEÍNA CRUDA
Mín. 16.0%
GRASA CRUDA
Máx. 5.5%
FIBRA CRUDA
Máx. 5.0%
CENIZAS
Máx. 12.0%
HUMEDAD
45.5%
E.L.N.
NUPEC® Hepatic
Formulated for the long-term management of chronic canine liver disease. It addresses the key pathophysiological axes: oxidative damage, progressive fibrosis, and the risk of hepatic encephalopathy. Silymarin — a hepatoprotectant with Class I evidence in veterinary hepatology — is the central ingredient, complemented by moderate, highly digestible protein with a favorable branched-chain amino acid profile, restricted copper (<5 ppm), and high caloric density. It does not restrict protein routinely, in line with WSAVA guidelines, except in documented hepatic encephalopathy.
Available presentations
2 kg
Ingredients
Rice, oats, dried egg, casein, poultry fat, barley, fish hydrolysate, coconut oil, fish oil, natural chicken flavor, beet pulp, chicory inulin, calcium, potassium chloride, salt, L-arginine, L-isoleucine, L-valine, choline chloride, taurine, L-carnitine, L-threonine, vitamin A supplement, cholecalciferol, alpha-tocopherol acetate, sodium bisulfite menadione complex, vitamin C, thiamine mononitrate, riboflavin, niacin, pyridoxine hydrochloride, vitamin B12 supplement, biotin, calcium pantothenate, folic acid, organic iron, organic manganese, organic selenium, organic zinc, ethylenediamine dihydroiodide, Silymarin, Yucca schidigera extract, rosemary and tocopherols as preservatives.
Warnings
Not recommended for pregnant or lactating females, or for growing puppies.
- Highly digestible animal-based protein sources (chicken meat meal, egg, casein) instead of relying mainly on plant protein.
- No unnecessary protein restriction.
- Maintains moderate, highly digestible protein levels (16% DM) with a favorable branched-chain amino acid profile, in line with WSAVA's recommendation not to routinely restrict protein except in documented hepatic encephalopathy.
- Copper strictly restricted to therapeutic levels (<5 ppm), relevant for breeds genetically predisposed to copper accumulation. Silymarin as an antioxidant, antifibrotic, anti-inflammatory, and hepatocyte-regenerating ingredient — not merely a secondary additive.
CLINICAL INDICATIONS
- ✓Food designed to support therapy in adult dogs of all breeds undergoing a hepatic condition clinically diagnosed by a veterinarian.
RxPrescription-only product. Requires veterinary diagnosis and follow-up.
CLINICAL DIFFERENTIATORS
AMMONIA DETOXIFICATION
- CONTROLLED INCLUSION OF MIXED PROTEINAnimal and plant sources of high biological quality
- AMINO ACID PROFILEElevated BCAAs that reduce nitrogenous compounds
- SOLUBLE FIBERGenerates an acidic pH that converts ammonia into ammonium
DUAL COPPER CONTROL
- COPPER < 5 PPMPrevents accumulation and toxic effects, reducing hepatic inflammation and fibrosis
- ORGANIC ZINCA copper antagonist at the intestinal level that decreases its absorption
HEPATOPROTECTION AND REGENERATION
- SILYMARIN 1000 PPMAn antioxidant that protects the liver, slows inflammation and fibrogenesis, and activates hepatocyte proliferation. Covers the needs of a dog up to 20 kg
- CHOLINEHelps prevent fat accumulation in the liver
ENERGY AND METABOLIC SUPPORT
- FISH OIL AND CHICKEN FATHighly digestible, palatable energy that stimulates intake
CLINICAL CHALLENGES AND NUTRITIONAL STRATEGY
Problem
Solution
Excessive protein restriction leads to muscle mass loss and malnutrition. In patients with hepatic encephalopathy, excess protein can increase ammonia production and worsen clinical signs.
Highly digestible, high biological quality protein (egg and casein) to maintain muscle mass and nitrogen balance.
Maintaining an adequate, highly digestible energy supply to limit catabolism and preserve muscle mass in patients with reduced appetite.
High energy density (fish oil, coconut oil, chicken fat) and selected carbohydrates (rice and oats) that help adequately cover energy needs.
In liver diseases caused by copper accumulation or altered biliary excretion, copper builds up in hepatocytes, increasing oxidative stress and promoting inflammation, hepatocellular damage, and fibrosis.
Ingredients naturally low in copper, selected to keep total intake below 5 PPM, with controlled zinc levels that help limit intestinal absorption.
Persistent inflammation and oxidative stress promote hepatocellular damage, fibrosis progression, and loss of liver function.
EPA+DHA as modulators of the inflammatory response; choline and silymarin with antioxidant and hepatoprotective activity.
MECHANISM OF ACTION
How NUPEC® Hepatic works in the body
REDUCTION OF HEPATIC ENCEPHALOPATHY
CONTROL OF COPPER-INDUCED OXIDATIVE DAMAGE
REGENERATION OF THE PARENCHYMA
PRESERVATION OF MUSCLE MASS
DOSING TABLE
| Description | Body weight | Daily amount |
|---|---|---|
| Adulto | 2 kg | 48 g - 1/2 taza |
| Adulto | 3 kg | 65 g - 2/3 taza |
| Adulto | 5 kg | 95 g - 1 taza |
| Adulto | 10 kg | 161 g - 1 3/5 taza |
| Adulto | 15 kg | 218 g - 2 1/5 taza |
| Adulto | 20 kg | 270 g - 2 2/3 taza |
| Adulto | 25 kg | 319 g - 3 1/5 taza |
| Adulto | 30 kg | 366 g - 3 2/3 taza |
| Adulto | 35 kg | 411 g - 4 tazas |
| Adulto | 40 kg | 454 g - 4 1/2 taza |
| Adulto | 45 kg | 496 g - 5 tazas |
| Adulto | 50 kg | 537 g - 5 2/5 taza |
| Adulto | 55 kg | 577 g - 5 3/4 taza |
| Adulto | 60 kg | 616 g - 6 tazas |
Ration calculator
Move the slider to see the approximate ration for the patient's weight.
48g
grams per day
Reference
Guideline values. Adjust according to the patient's clinical condition and veterinary recommendation.
Amount should be adjusted based on the patient's clinical condition. Consult with the attending veterinarian.
Dietary transition guide
General protocol for introducing NUPEC® CLINICAL formula
Day 1–3
75% previous food25% NUPEC® clinical
Day 4–6
50% previous food50% NUPEC® clinical
Day 7–9
25% previous food75% NUPEC® clinical
Day 10
0% previous food100% NUPEC® clinical
Any change in diet should be gradual. Mix the previous food with NUPEC® HEPATIC in a 3:1 ratio and gradually increase the amount. Keep in mind that each dog's nutritional needs vary depending on size, sex, breed, activity level, physiological stage, and ambient temperature. Consult your veterinarian
TECHNICAL RESOURCES — Hepatic
Downloadable material for animal health professionals
CLINICAL LINE
Select a product to view its complete technical datasheet.
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